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The SASP consists of a plethora of secreted factors, including pro-inflammatory cytokines, chemokines, growth factors, and extracellular matrix-degrading proteases, which profoundly influence the tissue microenvironment [56]

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Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies

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