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As melatonin production declines with age, many people turn to supplements during midlife to help with sleep changes

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When MetS is present, the prevalence of advanced fibrosis is almost doubled, and when all five MetS criteria are present, the prevalence of advanced fibrosis can reach 30% [67]

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So when they were launched on the market, they rapidly went into short supply they couldn't keep up with the number of prescriptions