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Probiotics like Bacteroides fragilis have shown promise in restoring gut bacterial balance, potentially alleviating GI symptoms and improving behavior

doi: 10.3389/fendo.2021.736867 18 WilliamsABabuJRWadsworthDDBurnettDGeethaT

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Furthermore, adipocytes are responsible for the functional alteration of the hypothalamic-pituitary-ovarian (HPO) axis due to aromatization of androgens to estrogens, which by negative feedback loop, suppress gonadotropin production [84,86]