Low-level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus
(PubMed) Boaz M, Smetana S, Weinstein T, et al
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In Figure 4G, H 2 O 2 induced 28% early apoptosis, while RGD-GHK and sOtx2-GHK prominently decreased the ratio of early apoptosis to approximately 21% (Figure 4E)
Discovered in 2015, it has become a central tool in research on AMPK signalling, metabolic homeostasis, and mitochondrial-nuclear crosstalk