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This pattern of regulation suggests a shift toward more favourable nitric oxide (NO) production, as eNOS and nNOS are typically involved in the generation of low, physiological levels of NO, which play key roles in maintaining vascular tone, blood flow, and neuronal function [68, 69]

10.1016/j.lfs.2021.119622 Life Sci

Alternatively, consider non-peptide weight loss medications or bariatric surgery for individuals with severe obesity unresponsive to pharmacotherapy