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In addition, in the study of PSCI, the regulation mechanism of microbiota-gut-brain-axis mediated by gut microbiota and its metabolites (such as gut probiotic metabolites) through vagus nerve and hypothalamus has gradually been reported (Lal et al., 2001)
doi: 10.1186/s12967-019-02196-9 532 U.S
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Vitamin B12 deficiency has been associated with peripheral neuropathy and even cognitive deficits, especially in older adults and those with HIV/AIDS, where it supports nerve function and assists in the maintenance of myelin sheath integrity