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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018

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The studied escalation started at 2mg weekly and increased by 2mg every 4 weeks to a 12mg maintenance dose

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