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Treated patients had significant stabilization in MDS-UPDRS-3 vs a worsening in those treated with placebo (see full publication in the NEJM)

6.3 Clinical Symptoms That Should Prompt Assessment Patients on GLP-1 therapy should seek review if experiencing: Persistent fatigue Hair thinning beyond expected telogen shift Neurological symptoms (numbness, tingling) Muscle weakness Persistent vomiting Severe dietary restriction These symptoms are non-specific but warrant nutritional evaluation

[4] [5] Patients should be aware that there is no official link established between GLP-1 therapy and improvement in rheumatoid arthritis symptoms or disease progression

10.4093/dmj.2016.40.5.339 101 KimY

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