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Consistent with this, lacking RING1B, a component of PRC1 complex, results in skewed differentiation patterns in mouse embryonic NSCs partially due to miss-regulation of Notch signaling pathway (Roman-Trufero et al., 2009)

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Our work over the past decade showed that the proteins that cause cancer (oncogenes) are neuroprotective [9,10,11,12,13] to post-mitotic photoreceptor cells, whereas anti-oncogenes inhibit tumor progression and promote retinal degeneration [14,15,16]