Laboratory applications explore the development of combination approaches that target multiple senescence mechanisms simultaneously, while research into biomarkers of senescent cell burden and senolytic administration efficacy enables better experimental monitoring and outcome assessment
doi: 10.1038/nchembio.2239 55 EnkeUSeyfarthLSchleussnerEMarkertUR
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However, the putative liver toxicity of methotrexate should be evaluated in the context of advances in our knowledge of the pathogenesis and natural history of liver disease, especially non-alcoholic fatty liver disease (NAFLD)
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