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Peer review Peer review information Nature Communications thanks Matteo Villa, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Biological Role and Mechanisms of Action GHK-Cu influences multiple cellular pathways that together support tissue regeneration

Previous studies have demonstrated that neutrophilic inflammation and MPO activity in the lung and sputum of COPD patients correlate well with disease progression (Park et al., 2013

Recruitment for ME/CFS patients started just before COVID related restrictions were introduced and research was suspended: one patient and one healthy control were recruited in February 2020, others from February 2021