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A compound can show clean short-term animal data and still present unforeseen problems in chronic human use this is a well-documented pattern in drug development history

Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: The SURMOUNT-4 randomized clinical trial

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Deuring JJ, Fuhler GM, Konstantinov SR et al (2014) Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohns disease

Introduction Glutathione is an antioxidant found in eukaryotic cells, most often in the reduced form (GSH)