The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]
Improved mood and mental clarity (11-14% of reviews) A subset of the energy-improvement group specifically mentions mood elevation, reduced anxiety, or "mental sharpness." This aligns with B12's role in neurotransmitter synthesis and methylation reactions affecting serotonin and dopamine pathways (Kennedy, Nutrients , 2016)
The result is improved blood glucose control
Reduced oxidative stress , which contributes to weight gain and inflammation
In this trial, 3,183 adult patients with inadequately controlled type 2 diabetes mellitus and atherosclerotic CV disease were randomized to RYBELSUS 14 mg once daily or placebo for a median observation time of 16 months
Compounded versions may provide an alternative during such times