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Recommended contraceptive options for individuals taking Ozempic include: Long-acting reversible contraception (LARC) : intrauterine devices (copper or hormonal), contraceptive implants, and injectable progestogens are highly effective and unaffected by gastrointestinal symptoms Barrier methods : condoms (male or female) provide reliable protection when used correctly and consistently Non-oral hormonal methods : contraceptive patches and vaginal rings may be suitable alternatives, though patients should discuss these with their healthcare provider Oral contraceptives : combined or progestogen-only pills remain effective options with Ozempic, but follow missed pill guidance if vomiting or severe diarrhoea occurs Regular review of contraceptive adequacy should form part of ongoing diabetes care consultations, particularly as weight loss progresses, which may increase fertility
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A person carrying the FTO rs9939609 risk variant may store fat preferentially in the abdomen and experience slower overall weight loss, while someone without this variant might see more rapid scale changes
The side-effect profile is gastrointestinal-dominant: nausea (44% in SUSTAIN trials), diarrhea (31%), constipation (24%), and vomiting (18%) (Sorli et al., Diabetes Care , 2017)
