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The lack of dose proportionality observed in SL apomorphine exposure appears to be more pronounced in patients with Parkinsons disease compared to healthy subjects, which may be attributed to extrinsic factors, such as SL film contact time under the tongue and dry mouth [27]

Neuroprotective effects of curcumin in neurodegenerative diseases

Despite promising findings, gaps in the evidence base, including the need for larger, long-term, and rigorously controlled trials, remain significant barriers to clinical translation

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This suggests an extensive crosstalk between mitochondria and lysosomes in apoptosis [86]