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In contrast, co-treatment of semaglutide with the amylin receptor agonist cagrilintide resulted in 29% of patients with obesity and T2D reporting nausea compared to 13% for cagrilintide alone and 16% for semaglutide alone (68)

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Major diabetes organizations, including the American Diabetes Association, recommend considering GLP-1 agonists in patients on metformin who have not reached their treatment targets, particularly those with cardiovascular disease or significant weight loss needs

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