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Additional risks specific to the bodybuilding context include: Cardiovascular strain: Increases in resting heart rate have been observed with GLP-1 receptor agonists as a class (as documented in the Summary of Product Characteristics for licensed agents such as semaglutide and tirzepatide)

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It adds psychiatric comorbidities, eating disorder history, and family dynamics as warranting assessment, and says adolescents under active psychiatric care should have input from their mental health provider before anything starts

If state Medicaid programs estimate the costs from expanded use will outweigh the savings, initial state Medicaid participation may be limited, especially given recent state budget challenges and federal funding cuts

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Moreover, the consumption of palatable food increases extracellular dopamine levels in the nucleus accumbens to regulate food-seeking behaviour 6,7