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Maintaining levels of activated folate may also aid in preventing depression.4-6 COMT (Catechol-O-methyltransferase) A common mutation in COMT, the conversion of the amino acid valine to methionine at positon 158 causes a dramatic reduction in its ability to break down neurotransmitters.7-9 Since COMT is central to dopamine metabolism, mutations are associated with lowered stress resiliency, increased sensitivity to pain10,11 and the propensity to worry

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Neurology 68 , S22S31 (2007)