Inflammatory markers (CRP, ESR) may also provide signal
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2.3 Free radical scavenging capacity of Ru SA+AC on oxidative stress rat chondrocytes in vitro An overabundance of RONS can lead to increased expression of inflammatory factors, mitochondrial impairment, and the induction of cell apoptosis, thereby accelerating the progression of OA[64]
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Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN