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(2007, Growth Hormone & IGF Research ) confirmed that following 300 eccentric lengthening contractions of the knee extensors in healthy young men, MGF mRNA expression peaked at 24 hours post-exercise while IGF-1Ea mRNA rose later at 72 hours providing direct in vivo human evidence of the sequential IGF-1 splice variant programme and establishing the temporal window for MGF-mediated satellite cell activation in physiological muscle damage

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Fatigue leads to less physical activity, which can lead to weight gain