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DOI: 10.1016/S0140-6736(23)01163-7

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Complexity and diversity of DAMPs Despite their potential therapeutic value, DAMP-targeted interventions face significant translational challenges

Because AOD-9604 and the incretins act through non-overlapping mechanisms (adipose lipolysis versus incretin signaling), some research protocols examine growth-hormone-fragment and incretin approaches in combination or in parallel arms which is why AOD-9604 appears as a "frequently paired" compound alongside semaglutide and tirzepatide

These results demonstrate that microbial TyrA orthologs from clade I, which contain an acidic residue at the corresponding 222 position (Figure 2, Data S2), are arogenate-specific TyrA a enzymes

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