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The key molecular pathway identified involves the activation of the general control nonderepressible 2 (GCN2) kinase, leading to the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2) and the upregulation of ATF4

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This suggests that the rise in Srd5a1 expression at the time of puberty is likely due to the increase in E2 levels and that the early life adversity either functions independently to repress Srd5a1 or might interfere with this activation

Sasturkar et al., 2016

(28, 29) Irritable Bowel Disease (IBD) Another major side effect of Accutane is irritable bowel disease, or IBD