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Erbil D, Eren CY, Demirel C, Kucuker MU, Solaroglu I, Eser HY
Shared mechanistic pathways of glucagon signalling: Unlocking its potential for treating obesity, metabolic dysfunction-associated steatotic liver disease, and other cardio-kidney-metabolic conditions
You might be wondering, Does what I eat while on GLP-1s actually matter? The short answer is yes, but not for the reasons you might think
ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, Collins BS, Cusi K, Das SR, Gibbons CH, Giurini JM, Hilliard ME, Isaacs D, Johnson EL, Kahan S, Khunti K, Kosiborod M, Leon J, Lyons SK, Gabbay RA (2022) Standards of care in diabetes2023
Additional receptor destinations involve retrograde transport towards the Golgi apparatus ( Evidence from primary mouse islets and clonal beta cells (INS-1 832/3) shows that Exenatide causes a greater amount of GLP-1R degradation compared to endogenous GLP-1, with this effect apparently due to differences in the susceptibility of the agonists for degradation by the endopeptidase endothelin converting enzyme 1 (ECE1) (Metzler et al., 2001) is associated with the control of GLP-1R function
Borah, Victor M
