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2 Researchers have been able to show through many studies that GLP-1 indirectly works in the liver by inhibiting glucagon secretion by pancreatic alpha-cells, thereby inhibiting gluconeogenesis and glycogenolysis, thus decreasing hepatic glucose production

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Mobile phase A (MPA) consisted of 60/40 acetonitrile/water with 10 mM ammonium formate and 0.1% formic acid, while mobile phase B (MPB) was composed of 89.1/9.9/0.99 isopropanol/acetonitrile/water with the same additives

the patients were current or ex-smoker with smoking pack-years 10

They compare patients initiating treatment in a given month to those who initiate 12 months later in a one-year follow-up design and 60 months later in a five-year follow-up design, allowing them to control for underlying time trends and baseline health differences

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