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Holen JP, Urriola PE, Schwartz M, Jang JC, Shurson GC, Johnston LJ

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No significant change in cortical bone volume was observed in the conditional knockouts compared to controls, possibly due to the fact that the trabecular compartment undergoes the highest rate of remodeling during the time of observation (Zhang et al., 2002)

Moreover, in a meta-analysis of eight trials, GLP-1RAs reduced MACE by 14% (HR 0.86, 95% CI 0.790.94), cardiovascular death by 13% (HR 0.87, 95% CI 0.780.96), and stroke by 16% (HR 0.84, 95% CI 0.760.94) [22] (Table 2)

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