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When excluding patients who had been diagnosed with diabetic retinopathy in the second sensitivity study, use of once-weekly semaglutide was still independently associated with a higher risk to develop NAION (adjusted HR 226, 95% CI 157 327) in a multivariable model adjusted as in the first sensitivity analysis
Branded products are manufactured in fixed-dose injector pens
The clinical data on dehydration rates in tirzepatide trials Published trial data underreports dehydration because "dehydration" as an adverse event requires clinical diagnosis
Glucose starvation decreases carbon flux, which leads to the depletion of PPP and NADPH, inhibition of the conversion of cystine to cysteine, and marked accumulation of cystine, a disulfide molecule [46,56]