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Mattingly says people with a lower BMI often have less fat mass and tissue to absorb the medication, so higher concentrations of the drug can enter the bloodstream (and ultimately take longer to be eliminated from the body)
They also slow gastric emptying, meaning that people feel fuller for longer after eating
However, frequent stop-start cycles often lead to frustration and weight cycling, which is why most doctors recommend either continuous therapy or extended pauses with strong behavioral support
At Atlanta Bariatrics, we believe in a holistic approach to weight loss
J Endocrinol 219:5968 [DOI] [PubMed] [Google Scholar] 45.Mieczkowska A, Mansur S, Bouvard B, Flatt PR, Thorens B, Irwin N, Chappard D, Mabilleau G (2015) Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength
