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Reconstitute with 2.0 mL of bacteriostatic water for a 5,000 mcg/mL solution

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This figure is remarkable in the context of GLP-1 therapeutics: oral semaglutide (Rybelsus), despite incorporating the SNAC absorption enhancer, achieves oral bioavailability of only 0.4-1.0%, meaning that more than 99% of the ingested semaglutide peptide is lost to gastrointestinal degradation and poor absorption

This discovery led to the approval of GLP-1 drugs for treating obesity, offering a fresh option for people struggling to manage their weight