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Published preclinical research on FOXO4-DRI has demonstrated selective elimination of senescent cells in mouse models, with observed improvements in fitness markers, fur density, and organ function in aged subjects

Several preclinical studies have shown that Quer in the myocardium can enhance the GSH antioxidant system by regulating multiple upstream molecular targets, such as peroxisome proliferator-activated receptor-gamma (PPAR-), phosphatidylinositide 3-kinase (PI3K)/serine/threonine kinase (AKT), and Nrf2 [120, 123, 124]

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