Also, taking B12 along with high-dose vitamin C or long-term antacids can affect how your body absorbs it
According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects
News Release May 16, 2022 Best Calcium and Bone Health Supplements Revealed by ConsumerLab Tests White Plains, New York, May 16, 2022 Calcium is essential for maintaining bones and plays critical roles in nerve transmission, muscle contraction, and the cardiovascular system
medRxiv (2023) 2004:23288404
It also messes with the skins PH
It has been shown previously that PTH or PTHrP ligand analogs can distinguish between two high-affinity PTHR1 conformations, R0 and RG, and that efficient binding to R0 results in prolonged signaling responses in cells and prolonged calcemic responses in animals, whereas selective binding to RG results in more transient responses
