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Many patients begin noticing results within 48 weeks , with continued weight loss over several months

With better control over glucose and weight, patients may experience improved long-term outcomes and easier management of their diabetes

Adverse effects also differ

Common side effects (affecting more than 10% of users) Nausea is the most frequently reported side effect, particularly during the first few weeks and after dose increases

This strategy makes GLP-1s accessible to individuals who may not need or want the effects of full-strength prescriptions but are still seeking manageable, steady progress

Retatrutides 24.2% average weight loss at 48 weeks approaches the results typically achieved through bariatric surgery, which produces 25-30% weight loss