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For flights, carry medication in carry-on luggage rather than checked baggage, where cargo hold temperatures may fall below freezing

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She notices reduced snacking in the first week, a small drop in weight by week three, and three to five pounds lost by week six while following the program

any insulin sensitivity improvement is largely secondary to weight loss

Phase 2 trials have shown remarkable weight-loss efficacy , with participants losing up to 24% of body weight at 48 weeks on higher doses