Muizzuddin, N., & Benjamin, R
The melanocortin system regulates expression of genes involved in thermogenesis, including uncoupling proteins in brown adipose tissue, contributing to increased energy expenditure independent of physical activity
The headline: most evidence is preclinical or from small, mostly Russian human studiespromising, but not yet canon
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However, these reports appear to be isolated and have not been corroborated by well-controlled studies, according to a review published in December 2024
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