Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects
The mechanisms are not yet fully understood in humans, but preclinical studies point to several overlapping pathways, said Hsiangkuo (Scott) Yuan, MD, associate professor at Thomas Jefferson University, clinical research director at Jefferson Headache Center, and one of the study authors
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Mechanically, insulin mainly activates two signal pathways: insulin receptor (IR)-insulin receptor substrates (IRS)-phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) signal pathway (Pollak, 2008)
