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tissue necrosis is exceedingly rare

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The copper(II) complex is sensitive to reducing conditions that would convert copper(II) to copper(I) and to chelating agents that would displace the copper

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Nat Genet (2007) 39(5):596604.10.1038/ng2032 153 SakiyamaTFujitaHTsubouchiH

Dietary intake of menaquinones and risk of cancer incidence and mortality