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In all cases, increased DNA methylation was inversely correlated with mRNA levels

These treatments face several hurdles: They don't lower uric acid enough in many patients [1] People with other health problems, especially kidney disease, can't take them [1] Starting these medications can actually trigger more flares [1] Patients struggle to stick with long-term treatment [1] This is a big deal as it means that about 80% of patients taking pegloticase (a powerful uric acid-lowering drug) get flares in the first three months, even with preventive treatment [1]

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10.1016/j.bbamcr.2019.118535 21

Weyer C et al