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Redness or Irritation Mild swelling or discomfort at the injection site

Nauck MA, Stockmanne F, Ebert R, Creutzfeldt W

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It has been shown that KPT-9274 can promote apoptosis and induce DNA damage in vitro, 312 and significantly reduces tumor proliferation and survival in xenograft models in different tumors, such as pancreatic cancer, 309 pancreatic neuroendocrine tumors, 313 triple-negative breast cancer 311 , and leukemia

However, long-term safety data is limited, and its full risk profile is not yet completely understood