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& Jasiulionis, M

Dil-LDL uptake assay Huh-7 cells were seeded in black transparent-bottom 96-well plates for 24 h and treated with experimental reagents for an additional 24 h

23,24 In a network meta-analysis, Karakasis et al found that 15 mg tirzepatide and 2.4 mg semaglutide were the most effective agents for reducing body weight and fat mass

While earlier trials in HFrEF (28, 29) were neutral or inconclusive, the STEP-HFpEF and SELECT trials highlighted robust improvements in patients with heart failure with preserved ejection fraction (HFpEF), particularly in obese phenotypes

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