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10.3390/molecules28052078 21 DaiY.CuiC.JiaoD.ZhuX

Chronic Fatigue: Persistent tiredness and lack of energy can be an early indicator

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The study included 521 patients and HbA1c was reduced by sitagliptin from 7.7% (61 mmol/mol) to 7.1% (54 mmol/mol), again with low risk for hypoglycemia and no weight gain

Cassidy CM, Zucca FA, Girgis RR, Baker SC, Weinstein JJ, Sharp ME, Bellei C, Valmadre A, Vanegas N, Kegeles LS, Brucato G, Kang UJ, Sulzer D, Zecca L, Abi-Dargham A, Horga G (2019) Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

And how much of the progress reverses