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As dozens of novel agents currently under study seek new indications, the question arises of whether the traditional practice of two confirmatory trials for every indication expansion remains justified, especially when database study emulations that benchmark against previously conducted, closely related reference trials have yielded aligned results 33,34

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Blood 70 : 14071411 Ameisen JC (1994) Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer

29 The prognosis of VPC-induced cardiomyopathy is good in patients without other cardiac problems

(5) When its in its reduced form, glutathione actively scavenges for free radicals