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January 18, 2021

In summary, GLP-1R on -cells is activated and promotes growth inhibitory hormone secretion, creating a multilayered inhibitory mechanism that effectively reduces glucagon secretion, and in turn lowers blood glucose levels

Despite the development of GLP-1 monoagonists, new peptides that combine the pharmacology of GLP-1 with other gut peptides increase the efficacy of these agonists while reducing their dose-related gastrointestinal side effects

Rapidly progressive weight loss or severe gastrointestinal symptoms warrant prompt provider contact

They can assess whether an alternative GLP-1 formulation or different medication class may be more suitable for your circumstances

The situation is part of a wider problem, with independent pharmacists often given lower reimbursement rates than larger retail chains