This mechanism is believed to play a key role in the pathogenesis of TED and is the basis for emergent therapeutic alternatives in patients with TED and, maybe, dermopathy
Whilst the NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, there is generally no benefit to consuming such excessive amounts unless treating confirmed deficiency under medical supervision
doi:10.1038/s41387-018-0017-1 Savic D, Hodson L, Neubauer S, Pavlides M
Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes
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