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In the absence of Clic4 or Schnurri-2, TGF-beta signalling is abrogated

Tyrrell RM

One side effect of these medications that came as a big surprise was tendon rupture

Toloza EM, Hunt K, Swisher S , McBride W, Lau R, Pang S, Rhoades K, Drake T, Belldegrun A, Glaspy J, Economou JS

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Through upregulating TP53 activity, GNA lowered the expression levels of GPX4 and SLC7A11, leading to dysregulation of cellular lipid peroxides, and eventually ferroptosis in transforming growth factor-1 (TGF-1)-induced EMT melanoma models (Wang et al., 2020)