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As you lose weight, your basal metabolic rate (the calories you burn at rest) may decrease, and your body may adjust by becoming more efficient with energya phenomenon known as adaptive thermogenesis

A mildly elevated lipase without abdominal pain does not establish pancreatitis

107,234 The varying weight loss observed for the different GLP-1 analogues currently used for T2D treatment has been suggested to be due to their ability to penetrate the CNS

These side effects are not exhaustive

In the over 2500 participants, who were assigned to the 5, 10, and 15 mg doses of tirzepatide and placebo, the percent weight changes were both statistically and clinically significant compared with placebo

Cost: These medications can be expensive, and fewer insurance companies are covering the cost as time goes on