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Endogenous timing remains regulated by hypothalamic GHRH and somatostatin oscillations, preserving physiologic rhythm structure in experimental models

Factors That May Affect Appropriateness According to general clinical guidance referenced in published sources, growth hormone secretagogues may not be appropriate for individuals with certain contraindications including active malignancies, uncontrolled diabetes, or other conditions that a clinician would evaluate during the prescribing process

Both follow the same pharmacokinetic principles for optimal weekly administration

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10.1016/j.biopha.2020.110985 Biomed Pharmacother