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The questionnaire screens: Do you suffer from any heart conditions? Severe CHF requires specialist cardiology review before any GLP-1 initiation and may be an absolute contraindication depending on ejection fraction and functional status

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At night, the thigh is often the easiest site because you can sit comfortably on your bed or a chair, clearly see the injection area, and reach it without contortion

It is a safety requirement

There is often a localized area of maximal tenderness over the anteromedial aspect of the inferior heel

one is alcohol, one smoking, the other is opiates