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The efficacy of probiotics for treatment of bipolar disorder-type 1: a randomized, double-blind, placebo controlled trial

Subsequent MRI spectroscopy work by the same group documented favorable shifts in brain metabolite ratios

NNMT is a metabolic enzyme that regulates cellular energy and methylation potential by preventing NAM (Nicotinamide) from participating in the NAD+ Salvage Pathway and converting back into NAD+

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If significant heterogeneity was found, the random effects model was used to analyze the data, while the fixed model was used if there was no significant heterogeneity