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Nanotechnol Environ Eng 8:109117

MIA reprograms microglia in a phenomenon known as trained immunity (otherwise known as innate immune memory) to enhance immune responses or suppress immune pathways to confer immune tolerance [51] via epigenetic modulations involving histone modifications, DNA methylation, chromatin remodeling, and miRNAs [52]

Until now, there is no concrete indication for Vit B12 therapy in order to moderate the motor burden of PD

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Mechanism: A synthetic tetrapeptide that activates telomerase, the enzyme responsible for extending telomeres, thereby promoting cellular longevity and delaying aging

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