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Both NAC and L-NAC pretreatments decreased IL-8 levels in untreated control cells and 0.25 mM PQ-challenged cells, while L-NAC, but not NAC, was also able to significantly reduce levels of IL-8 following 1.0 mM PQ challenge

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Small molecules that trigger ferroptosis identified thus far include agents that inhibit GPX4 directly, molecules that deplete the GPX4 cofactor glutathione, and compounds that oxidize iron 1,9,11,12

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