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Naltrexone and bupropion have independent actions in the brains reward system and in proopiomelanocortin (POMC) neurons of the hypothalamus, but it seems that the systemic effects of this combination produce a synergistic effect of decreasing food intake and weight

This GSH depletion effect is an indirect mechanism through which MTHFR impairment compounds the antioxidant capacity reductions from GCLC and GPX1 genetic insufficiency